Hollow Gold Nanoparticles Loaded with L-Buthionine-Sulfoximine as a Novel Nanomedicine for In Vitro Cancer Cell Therapy

A novel nanomedicine, constructed by simultaneously binding L-buthionine-sulfoximine (BSO) and thiolated polyethylene glycol (PEG) to the surface of 100 nm hollow gold nanoparticles (HAuNS), was expected be used in effective therapeutics cancer. The current study is aimed at evaluating vitro antitumor efficacy newly synthesized BSO-loaded PEG-SH-HAuNS (BSO@HAuNS) with strong resonances near-infrared (NIR) as a chemotherapy agents against line human lung cancer cells (A549). Here, we conducted cytotoxicity assays found BSO@HAuNS efficiently kill ROS generation, indicating that BSO facilitated an increased susceptibility PEG-SH-HAuNS. Based on flow cytometry analysis, can induce apoptosis necrosis mitochondrial-dependent pathway A549 cells. Our results revealed class nanomedicine high potential implemented for patients diagnosed unresectable